PGMEEnotes:-ANTI ARRHYTHMIC AGENTS

(Class of AAA-Main mech.-Mech.cont..-AGENTS)

CLASS I==Sodium channel Blockers (SCB)
CLASS-Ia=Fast sodium channel blocker=Depresses the phase0 depolarization, decreases Vmax & conductivity, increases A.P.D. & Refractoriness.
QuinidineProcaine amideDisopyramideMoricizine

CLASS-Ib=SCB=These agents decrease Vmax in partially depolarized cells with fast A.P.'s. Nochange/decrease A.P.D. & refractoriness
LidocaineMexilitineTocainidePhenytoin

CLASS-Ic=SCB=Markedly decreases Vmax & conductivity.Minimal effect on A.P.D.
FlecainidePropafenone

CLASS-II=Beta blockers=Slows conduction thru. A.V. node.EsmololPropanololMetaprolol

CLASS-III=Potassium channel blockers.=ProlongsRepolarization AmiodaroneSotalolbretyliumDofetilideIbutilide

CLASS-IV=Calcium channel blockers=Slows conduction thru. A.V. nodeVerapamilDiltiazem

CLASS-V=others
AdenocineDigoxin